Decoding flavonoid metabolism: a closer look at plant-based diets
Understanding how our bodies break down flavonoids from plants and how this process relates to their potential health benefits
Osaka Metropolitan University
An international team of researchers led by visiting researcher Tsutomu Shimada and Professor Shigeo Takenaka of the Graduate School of Human Life and Ecology at Osaka Metropolitan University, has shed light on the mechanism of three major flavonoids - naringenin, apigenin and genistein - and the processes by which the body metabolizes them. Molecular docking analyses revealed that human enzymes modify flavonoids in a similar way to how plants modify flavonoids.
“The results of this research are fundamental in elucidating the correlation between the metabolism of flavonoids in the body and their potential health benefits,” explained Professor Takenaka.
Original publication
Haruna Nagayoshi, Norie Murayama, Vitchan Kim, Donghak Kim, Shigeo Takenaka, Hiroshi Yamazaki, F. Peter Guengerich, Tsutomu Shimada; "Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1"; Chemical Research in Toxicology, Volume 36, 2023-10-2
Original publication
Haruna Nagayoshi, Norie Murayama, Vitchan Kim, Donghak Kim, Shigeo Takenaka, Hiroshi Yamazaki, F. Peter Guengerich, Tsutomu Shimada; "Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1"; Chemical Research in Toxicology, Volume 36, 2023-10-2
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